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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE3A
All Species:
16.36
Human Site:
S475
Identified Species:
30
UniProt:
Q14432
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14432
NP_000912.3
1141
124979
S475
L
Q
E
A
P
S
S
S
P
D
S
W
N
N
P
Chimpanzee
Pan troglodytes
XP_520783
1141
125048
S475
L
Q
E
A
P
S
S
S
P
D
S
W
N
N
P
Rhesus Macaque
Macaca mulatta
XP_001096963
1141
124707
S475
L
Q
E
A
P
S
S
S
P
D
S
F
N
S
L
Dog
Lupus familis
XP_854529
779
87136
S194
A
G
S
L
T
N
Q
S
P
I
E
F
P
D
T
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0X4
1141
124494
S472
P
H
E
A
P
S
P
S
A
V
N
P
D
S
W
Rat
Rattus norvegicus
Q62865
1141
124282
S472
P
H
E
A
P
S
P
S
A
V
N
P
D
S
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518516
340
38206
Chicken
Gallus gallus
XP_416416
825
91797
Q240
S
T
D
T
D
T
K
Q
G
L
K
P
H
K
V
Frog
Xenopus laevis
NP_001088828
985
108702
P400
P
R
R
A
G
A
S
P
S
L
S
P
V
N
S
Zebra Danio
Brachydanio rerio
XP_695432
1117
123518
P409
I
K
A
P
H
D
G
P
S
S
S
L
V
N
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W4T4
1209
129395
P410
I
K
L
K
F
R
K
P
H
K
S
C
W
S
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q8I0P7
625
69850
L40
G
S
I
G
L
P
V
L
G
G
R
G
R
G
V
Sea Urchin
Strong. purpuratus
XP_793920
1558
171759
S815
R
H
S
R
D
L
T
S
S
P
S
P
G
N
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.5
38.2
N.A.
84
84.6
N.A.
20.9
59.6
43.9
57.8
N.A.
20.8
N.A.
26.7
29.9
Protein Similarity:
100
99.7
98.4
49.6
N.A.
89.3
90
N.A.
25.1
63.9
58.3
71.2
N.A.
36.3
N.A.
37.9
43.2
P-Site Identity:
100
100
80
13.3
N.A.
33.3
33.3
N.A.
0
0
26.6
13.3
N.A.
6.6
N.A.
0
20
P-Site Similarity:
100
100
93.3
33.3
N.A.
53.3
53.3
N.A.
0
20
40
26.6
N.A.
26.6
N.A.
0
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
47
0
8
0
0
16
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
0
8
0
16
8
0
0
0
24
0
0
16
8
0
% D
% Glu:
0
0
39
0
0
0
0
0
0
0
8
0
0
0
0
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
0
16
0
0
0
% F
% Gly:
8
8
0
8
8
0
8
0
16
8
0
8
8
8
0
% G
% His:
0
24
0
0
8
0
0
0
8
0
0
0
8
0
0
% H
% Ile:
16
0
8
0
0
0
0
0
0
8
0
0
0
0
0
% I
% Lys:
0
16
0
8
0
0
16
0
0
8
8
0
0
8
0
% K
% Leu:
24
0
8
8
8
8
0
8
0
16
0
8
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
8
0
0
0
0
16
0
24
39
0
% N
% Pro:
24
0
0
8
39
8
16
24
31
8
0
39
8
0
16
% P
% Gln:
0
24
0
0
0
0
8
8
0
0
0
0
0
0
0
% Q
% Arg:
8
8
8
8
0
8
0
0
0
0
8
0
8
0
8
% R
% Ser:
8
8
16
0
0
39
31
54
24
8
54
0
0
31
24
% S
% Thr:
0
8
0
8
8
8
8
0
0
0
0
0
0
0
8
% T
% Val:
0
0
0
0
0
0
8
0
0
16
0
0
16
0
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
16
8
0
16
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _